Endocrine Abstracts

Background: Several studies have reported an association between serum 25-hydroxyvitamin D (25(OH)D) concentrations and pulmonary function in the general population. However, results remain conflicting. In addition, the underlying mechanisms by which vitamin D affects pulmonary function are unknown.Objective: To assess the relationship of vitamin D status with pulmonary function and whether this relationship is mediated by physical function and/or inflam...

Background: Fibrodysplasia ossificans progressiva (FOP) is a rare, genetic and devastating disease characterized by progressive heterotopic ossifications (HO) in muscles, tendons, ligaments and fascia. The formation of HO leads to severe contractures and early death. There are no approved medications yet. The STOPFOP team identified AZD0530 (saracatinib) as a potent, low nanomolar inhibitor of the mutant ALK2 kinase which is the unique genetic driver of this rare bone disease....